Identification of Triptophenolide from Tripterygium wilfordii as a Pan-antagonist of Androgen Receptor.

ABSTRACT: A compound, triptophenolide, derived from Tripterygium wilfordii was identified as an antiandrogen. Triptophenolide inhibits the activity of both wild-type and F876L mutant androgen receptors. Triptophenolide exhibits its antiandrogenic activity through competitive binding with androgen in the hormone-binding pocket, decreasing the expression of androgen receptor, and reducing the nuclear translocation of androgen receptor.

SUBMITTER: He Y 

PROVIDER: S-EPMC5150686 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature