A Novel Bioreactor System for the Assessment of Endothelialization on Deformable Surfaces.

ABSTRACT: The generation of a living protective layer at the luminal surface of cardiovascular devices, composed of an autologous functional endothelium, represents the ideal solution to life-threatening, implant-related complications in cardiovascular patients. The initial evaluation of engineering strategies fostering endothelial cell adhesion and proliferation as well as the long-term tissue homeostasis requires in vitro testing in environmental model systems able to recapitulate the hemodynamic conditions experienced at the blood-to-device interface of implants as well as the substrate deformation. Here, we introduce the design and validation of a novel bioreactor system which enables the long-term conditioning of human endothelial cells interacting with artificial materials under dynamic combin

SUBMITTER: Bachmann BJ 

PROVIDER: S-EPMC5150819 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature