Is there still room for additional common susceptibility alleles for venous thromboembolism?

ABSTRACT:

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Essentials Genetic architecture of venous thromboembolism (VTE) remains to be fully disentangled. 11 newly discovered candidate polymorphisms were genotyped in 3019 VTE cases and 2605 controls. None of the 11 polymorphisms were significantly associated with VTE risk. Additional major efforts are needed to identify VTE-associated genetic variants.

Summary

Background Through a meta-analysis of 12 genome-wide association studies, the International Network against VENous Thrombosis (INVENT) consortium identified two novel susceptibility loci for venous thromboembolism (VTE). This project has also generated other candidates that need to be confirmed. Objectives To assess the association with VTE of common single-nucleotide polymorphisms (SNPs) that demonstrated strong

SUBMITTER: Tregouet DA 

PROVIDER: S-EPMC5152582 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature