Polybrominated diphenyl ether exposure and reproductive hormones in North American men.

ABSTRACT:

Background

Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function.

Objectives

To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort.

Methods

From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models.

Results

PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH).

Conclu

SUBMITTER: Makey CM 

PROVIDER: S-EPMC5152616 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature