Cytotoxic gallium complexes containing thiosemicarbazones derived from 9-anthraldehyde: Molecular docking with biomolecules.

ABSTRACT: We have synthesized a trio of gallium complexes bearing 9-anthraldehyde thiosemicarbazones. The complexes were assessed for their anticancer activity and their biophysical reactivity was also investigated. The three complexes displayed good cytotoxic profiles against two human colon cancer cell lines, HCT-116 and Caco-2. The IC₅₀ ranged from 4.7 - 44.1 μM with the complex having an unsubstituted amino group on the thiosemicarbazone being the most active. This particular complex also showed a high therapeutic index. All three complexes bind strongly to DNA via intercalation with binding constants ranging from 7.46 × 10⁴ M^-1 to 3.25 × 10⁵ M^-1. The strength of the binding cannot be directly related to the level of anticancer activity. The

SUBMITTER: Beckford FA 

PROVIDER: S-EPMC5152947 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature