Correlation between SNPs in CDH1 and gastric cancer in Chinese population.

ABSTRACT:

Background

Many recent studies revealed that the single nucleotide polymorphisms have considerable effects on the susceptibility of cancer, such as prostate cancer, lung cancer and gastric cancer. The E-cadherin, a calcium-dependent transmembrane glycoprotein encoded by CDH1 gene, is critical for epithelial construction, intercellular adhesion and cell migration. Some associations have been reported between single nucleotide polymorphisms and gastric cancer in the Chinese population.

Objective

To investigate whether the single nucleotide polymorphism in CDH1 gene is associated with the susceptibility of gastric cancer in the Chinese population.

Material and methods

The genotypes of 5 known single nucleotide polymorphisms (rs33935154, rs121964871, rs121964874, rs121964

SUBMITTER: Lin Y 

PROVIDER: S-EPMC5152961 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature