Replication of Caucasian Loci Associated with Osteoporosis-related Traits in East Asians.

ABSTRACT:

Background

Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis.

Methods

A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269). The identified SNPs of osteoporosis-related traits in Korean subjects were included in the replication analysis using Chinese (n=2,327) and Japanese (n=768) cohorts.

Results

SUBMITTER: Kim BJ 

PROVIDER: S-EPMC5153380 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature