A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants.

ABSTRACT:

Background

Cluster Headache (CH) is a severe primary headache, with a poorly understood pathophysiology. Complex genetic factors are likely to play a role in CH etiology; however, no confirmed gene associations have been identified. The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms.

Methods

We have performed a genome-wide association study (GWAS) in a clinically well-defined cohort of 99 Italian patients with CH and in a control sample of 360 age-matched sigarette smoking healthy individuals, using the Infinium PsychArray (Illumina), which combines common highly-informative genome-wide tag SNPs and exonic SNPs. Genotype data were used to carry out a genome-wide single marker case-control associatio

SUBMITTER: Bacchelli E 

PROVIDER: S-EPMC5153392 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature