Rapid microwave-assisted synthesis of sub-30nm lipid nanoparticles.

ABSTRACT:

Hypothesis

Accessing the phase inversion temperature by microwave heating may enable the rapid synthesis of small lipid nanoparticles.

Experiments

Nanoparticle formulations consisted of surfactants Brij 78 and Vitamin E TPGS, and trilaurin, trimyristin, or miglyol 812 as nanoparticle lipid cores. Each formulation was placed in water and heated by microwave irradiation at temperatures ranging from 65°C to 245°C. We observed a phase inversion temperature (PIT) for these formulations based on a dramatic decrease in particle Z-average diameters. Subsequently, nanoparticles were manufactured above and below the PIT and studied for (a) stability toward dilution, (b) stability over time, (c) fabrication as a function of reaction time, and (d) transmittance of lipid nanoparticle dis

SUBMITTER: Dunn SS 

PROVIDER: S-EPMC5153442 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature