Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants.

ABSTRACT: A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested vaccine adjuvants, namely CAF01, IC31, GLA-SE and Alum in mice. We report signature molecules, pathways, gene modules and networks, which are shared by or otherwise exclusive to these clinical-grade adjuvants in whole blood and draining lymph nodes of mice. Intriguingly, co-expression analysis revealed blood gene modules highly enriched for molecules with documented roles in T follicular helper (TFH) and germinal center (GC) responses. We could show that all adjuvants enhance

SUBMITTER: Olafsdottir TA 

PROVIDER: S-EPMC5153655 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature