Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals.

ABSTRACT:

Background

Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN-sensitized and allergic subjects.

Methods

Basophil activation was determined by flow cytometric analyses of CD63 and CD203c expression using several HN allergen concentrations. Depending on their clinical reaction pattern, an oral allergy symptom group (OAS, n = 20), a systemic reaction group (n = 12) and a sensitized group without clinical symptoms (n = 20) were identified. Additionally, 10 non-allergic and non-sensitized individuals served as controls.

Results

CD63 and CD203c expression differed between allergic (OAS and systemic group) and sensitiz

SUBMITTER: Lotzsch B 

PROVIDER: S-EPMC5153676 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature