Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence.

ABSTRACT:

Background

Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.

Methods

Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.

Results

Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5153817 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature