A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans.

ABSTRACT: Molecular pathways involved in dauer formation, an alternate larval stage that allows Caenorhabditis elegans to survive adverse environmental conditions during development, also modulate longevity and metabolism. The decision to proceed with reproductive development or undergo diapause depends on food abundance, population density, and temperature. In recent years, the chemical identities of pheromone signals that modulate dauer entry have been characterized. However, signals derived from bacteria, the major source of nutrients for C. elegans, remain poorly characterized. To systematically identify bacterial components that influence dauer formation and aging in C. elegans, we utilized the individual gene deletion mutants in E. coli (K12). We identified 56 diverse E. coli deletion mutants

SUBMITTER: Khanna A 

PROVIDER: S-EPMC5153853 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature