Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection.

ABSTRACT: In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer's disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject selection, and be used as an outcome measure. A recent phase III trial of [¹⁸F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to identify fibrillar β-amyloid by comparing in vivo PET to post-mortem histopathology. Post-mortem analyses demonstrated a broad and continuous spectrum of β-amyloid pathology in AD and other dementing and non-dementing disease groups. The GE067-026 trial demonstrated 91% sensitivity and 90% specificity of [¹⁸F]flutemetamol PET by majority read for the presence of moderate or frequ

SUBMITTER: Ikonomovic MD 

PROVIDER: S-EPMC5154022 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature