Early kidney damage induced by subchronic exposure to PM_2.5 in rats.

ABSTRACT:

Background

Particulate matter exposure is associated with respiratory and cardiovascular system dysfunction. Recently, we demonstrated that fine particles, also named PM_2.5, modify the expression of some components of the angiotensin and bradykinin systems, which are involved in lung, cardiac and renal regulation. The endocrine kidney function is associated with the regulation of angiotensin and bradykinin, and it can suffer damage even as a consequence of minor alterations of these systems. We hypothesized that exposure to PM_2.5 can contribute to early kidney damage as a consequence of an angiotensin/bradykinin system imbalance, oxidative stress and/or inflammation.

Results

After acute and subchronic exposure to PM_2.5, lung damage was confir

SUBMITTER: Aztatzi-Aguilar OG 

PROVIDER: S-EPMC5154051 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature