Network Meta-analysis for Clinical Practice Guidelines: A Case Study on First-Line Medical Therapies for Primary Open-Angle Glaucoma.

ABSTRACT:

Background

Network meta-analysis compares multiple treatment options for the same condition and may be useful for developing clinical practice guidelines.

Purpose

To compare treatment recommendations for first-line medical therapy for primary open angle-glaucoma (POAG) from major updates of American Academy of Ophthalmology (AAO) guidelines with the evidence available at the time, using network meta-analysis.

Data sources

MEDLINE, Embase, and the Cochrane Library were searched on 11 March 2014 for randomized, controlled trials (RCTs) of glaucoma monotherapies compared with placebo, vehicle, or no treatment or other monotherapies. The AAO Web site was searched in August 2014 to identify AAO POAG guidelines.

Study selection

Eligible RCTs were selected by 2 indepe

SUBMITTER: Rouse B 

PROVIDER: S-EPMC5154244 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature