Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade.

ABSTRACT:

Objective

Although hypertension is the most common risk factor for thoracic aortic diseases, it is not understood how increased pressures on the ascending aorta lead to aortic aneurysms. We investigated the role of angiotensin II type 1 receptor activation in ascending aortic remodeling in response to increased biomechanical forces using a transverse aortic constriction (TAC) mouse model.

Approach and results

Two weeks after TAC, the increased biomechanical pressures led to ascending aortic dilatation and thickening of the medial and adventitial layers of the aorta. There was significant adventitial hyperplasia and inflammatory responses in TAC ascending aortas were accompanied by increased adventitial collagen, elevated inflammatory and proliferative markers, and increased

SUBMITTER: Kuang SQ 

PROVIDER: S-EPMC5154247 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature