Identification of differentially expressed miRNAs in individual breast cancer patient and application in personalized medicine.

ABSTRACT: MicroRNAs (miRNAs) have key roles in breast cancer progression, and their expression levels are heterogeneous across individual breast cancer patients. Traditional methods aim to identify differentially expressed miRNAs in populations rather than in individuals and are affected by the expression intensities of miRNAs in different experimental batches or platforms. Thus it is urgent to conduct miRNA differential expression analysis at an individual level for further personalized medicine research. We proposed a straightforward method to determine the differential expression of each miRNA in an individual patient by utilizing the reversal expression order of miRNA pairs between two conditions (cancer and normal tissue). We applied our method to breast cancer miRNA expression profiles from Th

SUBMITTER: Peng F 

PROVIDER: S-EPMC5154351 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature