MATE2 Expression Is Associated with Cancer Cell Response to Metformin.

ABSTRACT:

Background

There is great interest in repurposing the commonly prescribed anti-diabetic drug metformin for cancer therapy. Intracellular uptake and retention of metformin is affected by the expression of organic cation transporters (OCT) 1-3 and by multidrug and toxic compound extrusion (MATE) 1-2. Inside cells, metformin inhibits mitochondrial function, which leads to reduced oxygen consumption and inhibition of proliferation. Reduced oxygen consumption can lead to improved tumor oxygenation and radiation response.

Purpose

Here we sought to determine if there is an association between the effects of metformin on inhibiting oxygen consumption, proliferation and expression of OCTs and MATEs in a panel of 19 cancer cell lines.

Results

There was relatively large variabil

SUBMITTER: Chowdhury S 

PROVIDER: S-EPMC5154501 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature