Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study.

ABSTRACT:

Background

Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy. A subset of patients experience an increased mortality rate driven by two distinct clinical end points: histological transformation and early progression after immunochemotherapy. The nature of tumor clonal dynamics leading to these clinical end points is poorly understood, and previously determined genetic alterations do not explain the majority of transformed cases or accurately predict early progressive disease. We contend that detailed knowledge of the expansion patterns of specific cell populations plus their associated mutations would provide insight into therapeutic strategies and disease biology over the time course of FL clinical histories.

Methods and findings

Using a combination o

SUBMITTER: Kridel R 

PROVIDER: S-EPMC5154502 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature