Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms.

ABSTRACT: Small molecules of plant origin offer presumptively safe opportunities to prevent carcinogenesis, mutagenesis and other forms of toxicity in humans. However, the mechanisms of action of such plant-based agents remain largely unknown. In recent years the stress responsive transcription factor Nrf2 has been validated as a target for disease chemoprevention. Withania somnifera (WS) is a herb used in Ayurveda (an ancient form of medicine in South Asia). In the recent past, withanolides isolated from WS, such as Withaferin A (WA) have been demonstrated to be preventive and therapeutic against multiple diseases in experimental models. The goals of this study are to evaluate withanolides such as WA as well as Withania somnifera root extract as inducers of Nrf2 signaling, to probe the underlying s

SUBMITTER: Palliyaguru DL 

PROVIDER: S-EPMC5154810 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature