T-cell Activation and E-selectin Are Associated With Coronary Plaque in HIV-infected Young Adults.

ABSTRACT: We evaluated immune activation and coronary artery plaque in young adults with human immunodeficiency virus acquired in early life (n = 31). Coronary plaque was positively associated with lipids, immune activation marker %CD8+CD38+DR+ and E-selectin, a marker of endothelial inflammation. Immune activation and endothelial inflammation may drive coronary plaque formation during the early stages of atherosclerosis in the context of chronic human immunodeficiency virus.

SUBMITTER: Mattingly AS 

PROVIDER: S-EPMC5154863 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature