An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.

ABSTRACT:

Objectives

Disturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a large sample of bipolar I patients, non-affected siblings and controls.

Methods

A total of 107 bipolar disorder I patients, 74 non-affected siblings, and 80 controls were included. Sleep was measured with actigraphy over the course of 14 days. Seven sleep parameters were analyzed for group differences and their relationship with age at onset, number of episodes and psychotic symptoms using linear mixed model analysis to account for family dependencies.

Results

SUBMITTER: Verkooijen S 

PROVIDER: S-EPMC5154955 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature