Ontology highlight
ABSTRACT:
SUBMITTER: Marimon O
PROVIDER: S-EPMC5155140 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nature communications 20161208
The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In contrast to other TA systems, [C117S]YmoB transiently interacts with Hha (rather than forming a stable complex) and enhances the spontaneous oxidation of the Hha conserved cysteine residue to a -SO<sub>x</sub>H-containing species (sulfenic, sulfinic o ...[more]