Ontology highlight
ABSTRACT:
SUBMITTER: Van Emburgh BO
PROVIDER: S-EPMC5155160 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Nature communications 20161208
Blockade of the epidermal growth factor receptor (EGFR) with the monoclonal antibodies cetuximab or panitumumab is effective in a subset of colorectal cancers (CRCs), but the emergence of resistance limits the efficacy of these therapeutic agents. At relapse, the majority of patients develop RAS mutations, while a subset acquires EGFR extracellular domain (ECD) mutations. Here we find that patients who experience greater and longer responses to EGFR blockade preferentially develop EGFR ECD mutat ...[more]