Prior knowledge guided eQTL mapping for identifying candidate genes.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) mapping is often used to identify genetic loci and candidate genes correlated with traits. Although usually a group of genes affect complex traits, genes in most eQTL mapping methods are considered as independent. Recently, some eQTL mapping methods have accounted for correlated genes, used biological prior knowledge and applied these in model species such as yeast or mouse. However, biological prior knowledge might be very limited for most species.

Results

We proposed a data-driven prior knowledge guided eQTL mapping for identifying candidate genes. At first, quantitative trait loci (QTL) analysis was used to identify single nucleotide polymorphisms (SNP) markers that are associated with traits. Then co-expressed gene mod

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5155383 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature