The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease.

ABSTRACT:

Importance

The contribution of cardiovascular disease (CV) and cerebrovascular disease to the risk for late-onset Alzheimer disease (LOAD) has been long debated. Investigations have shown that antecedent CV risk factors increase the risk for LOAD, although other investigations have failed to validate this association.

Objective

To study the contribution of CV risk factors (type 2 diabetes, hypertension, and heart disease) and the history of stroke to LOAD in a data set of large families multiply affected by LOAD.

Design, setting, and participants

The National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease family study (hereinafter referred to as NIA-LOAD study) is a longitudinal study of families with multiple members af

SUBMITTER: Tosto G 

PROVIDER: S-EPMC5155512 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature