Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid.

ABSTRACT: We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis.

SUBMITTER: Yang X 

PROVIDER: S-EPMC5155590 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature