Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.

ABSTRACT:

Context

Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response.

Objective

We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol.

Design

Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy.

Setting

Hospital antenatal clinics.

Participants

A total of 829 pregnant women (422 placebo, 407 cholecalciferol). At 14 and 34 weeks of gestation, maternal anthropometry, health, and lifestyle were assessed and 25(OH)D measured. Compliance was determined using pill counts at 19 and 34 weeks.

Interventions<

SUBMITTER: Moon RJ 

PROVIDER: S-EPMC5155676 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature