Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature.

ABSTRACT:

Context

Growth of short children in puberty is limited by the effect of estrogen on epiphyseal fusion.

Objectives

To compare: 1) the efficacy and safety of aromatase inhibitors (AIs) vs GH vs AI/GH on increasing adult height potential in pubertal boys with severe idiopathic short stature (ISS); and 2) differences in body composition among groups.

Design

Randomized three-arm open-label comparator.

Setting

Outpatient clinical research.

Patients

Seventy-six pubertal boys [mean (SE) age, 14.1 (0.1) years] with ISS [height SD score (SDS), -2.3 (0.0)].

Intervention

Daily AIs (anastrozole or letrozole), GH, or AI/GH for 24-36 months.

Outcomes

Anthropometry, bone ages, dual x-ray absorptiometry, spine x-rays, hormones, safety labs.

Results

H

SUBMITTER: Mauras N 

PROVIDER: S-EPMC5155684 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature