Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.

ABSTRACT: Cerebral Cavernous Malformation (CCM) is a vascular disease of proven genetic origin, which may arise sporadically or is inherited as an autosomal dominant condition with incomplete penetrance and highly variable expressivity. CCM lesions exhibit a range of different phenotypes, including wide inter-individual differences in lesion number, size, and susceptibility to intracerebral hemorrhage (ICH). Lesions may remain asymptomatic or result in pathological conditions of various type and severity at any age, with symptoms ranging from recurrent headaches to severe neurological deficits, seizures, and stroke. To date there are no direct therapeutic approaches for CCM disease besides the surgical removal of accessible lesions. Novel pharmacological strategies are particularly needed to limit d

SUBMITTER: Retta SF 

PROVIDER: S-EPMC5155701 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature