Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure.

ABSTRACT:

Background

The candidate malaria vaccine RTS,S/AS01E has entered phase 3 trials, but data on long-term outcomes are limited.

Methods

For 4 years, we followed children who had been randomly assigned, at 5 to 17 months of age, to receive three doses of RTS,S/AS01E vaccine (223 children) or rabies vaccine (224 controls). The end point was clinical malaria (temperature of ≥37.5°C and Plasmodium falciparum parasitemia density of >2500 parasites per cubic millimeter). Each child's exposure to malaria was estimated with the use of the distance-weighted local prevalence of malaria.

Results

Over a period of 4 years, 118 of 223 children who received the RTS,S/AS01E vaccine and 138 of 224 of the controls had at least 1 episode of clinical malaria. Vaccine efficacies in the inten

SUBMITTER: Olotu A 

PROVIDER: S-EPMC5156295 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature