Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology.

ABSTRACT: The Framingham Heart Study (FHS) has conducted seminal research defining cardiovascular disease (CVD) risk factors and fundamentally shaping public health guidelines for CVD prevention over the past five decades. The success of the Original Cohort, initiated in 1948, paved the way for further epidemiological research in preventive cardiology. Due to the keen observations suggesting the role of shared familial factors in the development of CVD, in 1971 the FHS began enroling the second generation cohort, comprising the children of the Original Cohort and the spouses of the children. In 2002, the third generation cohort, comprising the grandchildren of the Original Cohort, was initiated to additionally explore genetic contributions to CVD in greater depth. Additionally, because of the predom

SUBMITTER: Tsao CW 

PROVIDER: S-EPMC5156338 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature