Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms.

ABSTRACT:

Purpose

Dry eye is associated with inflammation, pain, and discomfort. Vitamin D is known to modulate immune responses and pain. This study investigates the level of serum vitamin D and tear-inflammatory proteins with relation to exaggerated symptoms in patients with mild dry eye.

Methods

Patients with mild dry eye signs (Dry Eye Workshop [DEWS] severity grade 1) but with exaggerated symptoms and healthy controls (n = 19, each) were recruited for this cross-sectional study. Schirmer's Test I (mm), tear film break-up time (TBUT; secs), and ocular surface disease index (OSDI) score were recorded. Serum vitamin D level and tear cytokine levels were measured.

Results

The mean OSDI score in the patient cohort (46 ± 3) was significantly higher than controls (8.4 ± 1.

SUBMITTER: Shetty R 

PROVIDER: S-EPMC5156440 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature