MyD 88 Polymorphisms in Children Diagnosed with Sepsis.

ABSTRACT:

Background

Myeloid differentiation primary response gene 88 (MyD 88) is an intracellular adapter protein that mediates the early immune response to pathogens. Toll-like receptors (except TLR-3) induce the immune response through a MyD 88-dependent signal pathway.

Aims

We aimed to investigate the MyD 88 polymorphisms that play important roles in the immune response in septic children and to evaluate whether or not they were risk factors in the development of sepsis.

Study design

Case-control study.

Methods

Sixty-five patients diagnosed with sepsis in the Pediatric Intensive Care Unit during the period from April 2010 to January 2012 were included as the study group. Sixty-five children without sepsis were included as controls. After DNA was obtained from blood s

SUBMITTER: Gokay SS 

PROVIDER: S-EPMC5156451 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature