Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis.

ABSTRACT:

Background

Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders.

Aims

To investigate the relationship between the MIF gene -173 G/C single-nucleotide polymorphism (SNP) and AS.

Study design

Cross-sectional study.

Methods

In this study, a total of 161 AS and 194 normal controls were recruited. The MIF gene -173 G/C SNP was analyzed by polymerase chain reaction using the restriction fragment length polymorphism method.

Results

There was no significant difference between groups

SUBMITTER: Gurel C 

PROVIDER: S-EPMC5156461 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature