Ontology highlight
ABSTRACT:
SUBMITTER: Akbari M
PROVIDER: S-EPMC5156482 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Akbari Mansour M Keijzers Guido G Maynard Scott S Scheibye-Knudsen Morten M Desler Claus C Hickson Ian D ID Bohr Vilhelm A VA
DNA repair 20140227
Base excision repair (BER) is the most prominent DNA repair pathway in human mitochondria. BER also results in a temporary generation of AP-sites, single-strand breaks and nucleotide gaps. Thus, incomplete BER can result in the generation of DNA repair intermediates that can disrupt mitochondrial DNA replication and transcription and generate mutations. We carried out BER analysis in highly purified mitochondrial extracts from human cell lines U2OS and HeLa, and mouse brain using a circular DNA ...[more]