Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice.

ABSTRACT: Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3⁺ T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3⁺ regulatory T cells (Tregs). Furthermore, SYR treatment significantly enhanced the Firmicutes/Bacteroidetes ratio compared with that in age-matched controls by increasing beneficial bacteria, Lactobacillus and Bifidobacterium, while reducing the opportunistic pa

SUBMITTER: Cho SY 

PROVIDER: S-EPMC5157019 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature