Acetylcholine released by endothelial cells facilitates flow-mediated dilatation.

ABSTRACT:

Key points

The endothelium plays a pivotal role in the vascular response to chemical and mechanical stimuli. The endothelium is exquisitely sensitive to ACh, although the physiological significance of ACh-induced activation of the endothelium is unknown. In the present study, we investigated the mechanisms of flow-mediated endothelial calcium signalling. Our data establish that flow-mediated endothelial calcium responses arise from the autocrine action of non-neuronal ACh released by the endothelium.

Abstract

Circulating blood generates frictional forces (shear stress) on the walls of blood vessels. These frictional forces critically regulate vascular function. The endothelium senses these frictional forces and, in response, releases various vasodilators that relax smooth mu

SUBMITTER: Wilson C 

PROVIDER: S-EPMC5157078 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature