Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation.

ABSTRACT: Although B cells are traditionally known for their role in propagating proinflammatory immune responses, their immunosuppressive effects have only recently begun to be appreciated. How these regulatory B cells (B_regs) suppress the immune response remains to be worked out in detail. In this article, we show that B_regs can induce the formation of conventional FoxP3⁺ regulatory T cells (T_regs), as well as a more recently described CD49b⁺CD223⁺ regulatory T-cell subset, known as type 1 regulatory T cells (Tr1s). When B_regs are transferred into mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, they home to the spleen and mesenteric lymph nodes, leading to an expansion of T<

SUBMITTER: Pennati A 

PROVIDER: S-EPMC5157105 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature