Clinical and Biological Insights Into Combined Post- and Pre-Capillary Pulmonary Hypertension.

ABSTRACT:

Background

Pulmonary hypertension (PH) is a common and morbid complication of left heart disease with 2 subtypes: isolated post-capillary pulmonary hypertension (Ipc-PH) and combined post-capillary and pre-capillary pulmonary hypertension (Cpc-PH). Little is known about the clinical or physiological characteristics that distinguish these 2 subphenotypes or if Cpc-PH shares molecular similarities to pulmonary arterial hypertension (PAH).

Objectives

The goal of this study was to test the hypothesis that the hemodynamic and genetic profile of Cpc-PH would more closely resemble PAH than Ipc-PH.

Methods

Vanderbilt University's electronic medical record linked to a DNA biorepository was used to extract demographic characteristics, clinical data, invasive hemodynamic data, e

SUBMITTER: Assad TR 

PROVIDER: S-EPMC5157701 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature