Present Yourself! By MHC Class I and MHC Class II Molecules.

ABSTRACT: Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is a story of the proteases and MHC-like chaperones that support the MHC class I and II molecules in presenting peptides to the immune system. We now understand that the MHC system shapes both the repertoire of presented peptides and the subsequent T cell response, with important implications ranging from transplant rejection to tumor immunotherapies. Here we present an illustrated review of the ins and outs of MHC class I and MHC class II antigen presentation.

SUBMITTER: Rock KL 

PROVIDER: S-EPMC5159193 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature