Higher insulin and higher body fat via leptin are associated with disadvantageous decisions in the Iowa gambling task.

ABSTRACT: Elevated body mass index and post-prandial state are associated with disadvantageous choices on the Iowa Gambling Task (IGT). Whether physiological factors including percent body fat, and peripheral glucose, insulin, and leptin concentrations, are associated with IGT performance is unknown. In196 healthy adults without diabetes, we measured body fat by DXA scan, glucose, insulin and leptin (n=138) concentrations during an oral glucose tolerance test and IGT performance after a standardized meal. Glucose was not associated with IGT performance. Disadvantageous IGT performance was associated with higher percent body fat (r=-0.16, p=0.03), 30-min insulin concentrations (insulin₃₀, r=-0.27, p<0.001), and 30-min leptin concentrations (leptin₃₀, r=-0.23, p=0.008). Mediation

SUBMITTER: Chang DC 

PROVIDER: S-EPMC5159212 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature