Clinical and Molecular Characteristics of Post-Colonoscopy Colorectal Cancer: A Population-based Study.

ABSTRACT:

Background & aims

Colonoscopy provides incomplete protection from colorectal cancer (CRC), but determinants of post-colonoscopy CRC are not well understood. We compared clinical features and molecular characteristics of CRCs diagnosed at different time intervals after a previous colonoscopy.

Methods

We performed a population-based, cross-sectional study of incident CRC cases in Denmark (2007-2011), categorized as post-colonoscopy or detected during diagnostic colonoscopy (in patients with no prior colonoscopy). We compared prevalence of proximal location and DNA mismatch repair deficiency (dMMR) in CRC tumors, relative to time since previous colonoscopy, using logistic regression and cubic splines to assess temporal variation.

Results

Of 10,365 incident CRCs, 725 occu

SUBMITTER: Stoffel EM 

PROVIDER: S-EPMC5159224 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature