Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.

ABSTRACT:

Purpose

Cognitive behavioral stress management (CBSM) is an empirically-validated group-based psychosocial intervention. CBSM is related to decreased self-reported indicators of psychological adversity during breast cancer treatment and greater disease-free survival (DFS) vs. a control condition. This study examined relationships between CBSM, DFS, and a potential biobehavioral pathway linking these variables in breast cancer patients through a gene expression composite representing the leukocyte conserved transcriptional response to adversity (CTRA).

Design

Women with stage 0-IIIb breast cancer completed questionnaires and provided blood samples post-surgery. Participants were randomized to 10-week group-based CBSM or a psychoeducation control group and followed at 6 months

SUBMITTER: Antoni MH 

PROVIDER: S-EPMC5159236 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature