Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.

ABSTRACT:

Background & aims

The 5-hydroxytryptamine receptor 4 (5-HT₄R or HTR₄) is expressed in the colonic epithelium but little is known about its functions there. We examined whether activation of colonic epithelial 5-HT₄R protects colons of mice from inflammation.

Methods

The 5-HT₄R agonist tegaserod (1 mg/kg), the 5-HT₄R antagonist GR113808 (1 mg/kg), or vehicle (control) were delivered by enema to wild-type or 5-HT₄R knockout mice at the onset of, or during, active colitis, induced by administration of dextran sodium sulfate or trinitrobenzene sulfonic acid. Inflammation was measured using the colitis disease activity index and by histologic analysis of intestinal tissues. Epithelial proliferation, wound healing,

SUBMITTER: Spohn SN 

PROVIDER: S-EPMC5159265 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature