Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally.

ABSTRACT: Prenatal alcohol exposure (PAE) is associated with extremely high rates of psychopathologies, which may be mediated by the hypothalamic-pituitary-adrenal (HPA) dysregulation observed in exposed individuals. Of relevance, PAE carries an increased risk of exposure to stressful environments throughout life. Importantly, stressful experiences during adolescence increase vulnerability to psychopathologies. However, little is known about how adolescent stressful experiences in the context of PAE-induced HPA dysregulation may further alter the developmental trajectory and potentially contribute to the disproportionally high rate of psychopathologies observed in this population. Here we investigate the short- and long-term effects of adolescent chronic mild stress (CMS) on the emergence of anxiety

SUBMITTER: Raineki C 

PROVIDER: S-EPMC5159267 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature