Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention.

ABSTRACT: A number of studies have reported that type 2 diabetes mellitus (T2DM) is associated with alterations in resting-state activity and connectivity in the brain. There is also evidence that interventions involving physical activity and weight loss may affect brain functional connectivity. In this study, we examined the effects of nearly 10 years of an intensive lifestyle intervention (ILI), designed to induce and sustain weight loss through lower caloric intake and increased physical activity, on resting-state networks in adults with T2DM. We performed a cross-sectional comparison of global and local characteristics from functional brain networks between individuals who had been randomly assigned to ILI or a control condition of health education and support. Upon examining brain networks from

SUBMITTER: Casanova R 

PROVIDER: S-EPMC5159283 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature