Calibrated bold fMRI with an optimized ASL-BOLD dual-acquisition sequence.

ABSTRACT: Calibrated fMRI techniques estimate task-induced changes in the cerebral metabolic rate of oxygen (CMRO₂) based on simultaneous measurements of cerebral blood flow (CBF) and blood-oxygen-level-dependent (BOLD) signal changes evoked by stimulation. To determine the calibration factor M (corresponding to the maximum possible BOLD signal increase), BOLD signal and CBF are measured in response to a gas breathing challenge (usually CO₂ or O₂). Here we describe an ASL dual-acquisition sequence that combines a background-suppressed 3D-GRASE readout with 2D multi-slice EPI. The concatenation of these two imaging sequences allowed separate optimization of the acquisition for CBF and BOLD data. The dual-acquisition sequence was validated by comparison to an ASL seque

SUBMITTER: Fernandez-Seara MA 

PROVIDER: S-EPMC5159288 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature