Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques.

ABSTRACT:

Background

Experimental evidence correlates anesthetic exposure during early development with neuronal and glial injury and death, as well as behavioral and cognitive impairments, in young animals. Several, although not all, retrospective human studies of neurocognitive and behavioral disorders after childhood exposure to anesthesia suggest a similar association. Few studies have specifically investigated the effects of infant anesthesia exposure on subsequent neurobehavioral development. Using a highly translational nonhuman primate model, the authors investigated the potential dose-dependent effects of anesthesia across the first year of development.

Methods

The authors examined the effects of single or multiple early postnatal isoflurane exposures on subsequent behavioral

SUBMITTER: Coleman K 

PROVIDER: S-EPMC5159295 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature